Is Alpha-Damascone safe in cosmetics?
Alpha-Damascone has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
MODERATE
Cosmetic Ingredient
Alpha-Damascone
Also known as: FEMA No. 3659, 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one, 4-(2,6,6-Trimethyl-2-cyclohexenyl)-2-buten-4-one, UNII-UP5JTZ982I
INCI: ALPHA-DAMASCONE
Alpha-Damascone (CAS 43052-87-5) is a cosmetic cosmetic ingredient functioning as Perfuming — rose/fruity ketone fragrance. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 43052-87-5 →
Function
Perfuming — rose/fruity ketone fragrance
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-1-one
InChIKey
GCGZDUFEEQNVPR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Permitted with IFRA restrictions. Category 1 (lip products applied to lips/toys) prohibited; Categories 2–11 have specific concentration limits.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Alpha-Damascone.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
133 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [568] RIFM (1985): RIFM report number 15416, July 29, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 135 | - | - |
| HRIPT | - | 0 | 133 | - | - |
| HRIPT | - | 0 | 500 | - | - |
| HRIPT | - | 0 | - | - | - |
| HRIPT | - | 0 | - | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
385
Source: WHO/JECFA
JECFA Evaluation
alpha-DAMASCONE | 2002 | No safety concern at current levels of intake when used as a flavouring agen | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 42-JECFA 51/335 (1998)
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Alpha-Damascone — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
FEMA No. 3659
1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one
4-(2,6,6-Trimethyl-2-cyclohexenyl)-2-buten-4-one
UNII-UP5JTZ982I
Chemical Function
Fragrance
Deodorizer
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ALPHA-DAMASCONE
ADI
No safety concern at current levels of intake when used as a flavouring agen mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Alpha-Damascone allowed in the EU?
Alpha-Damascone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Alpha-Damascone do in cosmetics?
Alpha-Damascone functions as: Perfuming — rose/fruity ketone fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 43052-87-5.
Is Alpha-Damascone used outside cosmetics?
Alpha-Damascone also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Alpha-Damascone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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