Is Alpha-Phellandrene safe in cosmetics?
Alpha-Phellandrene has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Alpha-Phellandrene
Also known as: 3-05-00-00342, BRN 1280394, EINECS 202-792-5, FEMA No. 2856, 1-Isopropyl-4-methyl-2,4-cyclohexadiene (+11 more)
INCI: ALPHA-PHELLANDRENE
Alpha-Phellandrene (CAS 99-83-2) is a cosmetic cosmetic ingredient functioning as Fragrance (Perfuming), Flavoring — naturally occurring monoterpene in. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 99-83-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Alpha-Phellandrene is classified GHS Danger (H304, H317, H226) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance (Perfuming), Flavoring — naturally occurring monoterpene in eucalyptus, dill, and other essential oils
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-methyl-5-propan-2-ylcyclohexa-1,3-diene
InChIKey
OGLDWXZKYODSOB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA; FEMA GRAS
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Alpha-Phellandrene.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2592 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [764] Kligman AM (1972): Reports to RIFM, 14 March and 13 October, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
| HMT | - | 0 | 5184 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (5)
JECFA Number
1328
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
5-ISOPROPYL-2-METHYL-1,3-CYCLOHEXADIENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
alpha-PHELLANDRENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p-MENTHA-1,5-DIENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIHYDRO-p-CYMENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Alpha-Phellandrene.
Regulatory Flags
essential-oil
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
3-05-00-00342
BRN 1280394
EINECS 202-792-5
FEMA No. 2856
1-Isopropyl-4-methyl-2,4-cyclohexadiene
4-Isopropyl-1-methyl-1,5-cyclohexadiene
(-)-2-Methyl-5-(1-methylethyl)-1,3-cyclohexadiene
UNII-49JV13XE39
1-methyl-4-isopropyl-1,5-cyclohexadiene
2-methyl-5-isopropyl-1,3-cyclohexadiene
5-isopropyl-2-methylcyclohexa-1,3-diene
FEMA 2856
a-Phellandrene
alpha-Phellandren
alpha-fellandrene
dihydro-p-cymene
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
air; Cleaning products and household care; detected; emissions
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188459
Frequently Asked Questions
Is Alpha-Phellandrene allowed in the EU?
Alpha-Phellandrene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Alpha-Phellandrene do in cosmetics?
Alpha-Phellandrene functions as: Fragrance (Perfuming), Flavoring — naturally occurring monoterpene in eucalyptus, dill, and other essential oils. It is classified as a cosmetic ingredient in our database. CAS number: 99-83-2.
Is Alpha-Phellandrene used outside cosmetics?
Alpha-Phellandrene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Alpha-Phellandrene have different safety status in cosmetics vs industrial chemicals?
Alpha-Phellandrene is classified GHS Danger (H304, H317, H226) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Alpha-Phellandrene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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