Regulatory Status
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Safety Data
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Expert Verdict
Sub-acute oral toxicity studies in rats showed hepatotoxicity (centrilobular necrosis) at 500–1000 mg/kg doses. Indole alkaloids are pharmacologically active and bark extract has been developed as a botanical drug for bronchitis. Supplier alkaloid content specifications must be obtained and systemic exposure potential carefully evaluated due to highest risk profile in this category.
Regulatory Flags
Frequently Asked Questions
Is Alstonia Scholaris Bark Extract safe in cosmetics?
Sub-acute oral toxicity studies in rats showed hepatotoxicity (centrilobular necrosis) at 500–1000 mg/kg doses. Indole alkaloids are pharmacologically active and bark extract has been developed as a botanical drug for bronchitis. Supplier alkaloid content specifications must be obtained and systemic exposure potential carefully evaluated due to highest risk profile in this category. The EU classifies Alstonia Scholaris Bark Extract as "permitted". Safety rating: MODERATE.
Is Alstonia Scholaris Bark Extract allowed in the EU?
Alstonia Scholaris Bark Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Alstonia Scholaris Bark Extract do in cosmetics?
Alstonia Scholaris Bark Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 85085-82-7.
What is the Margin of Safety for Alstonia Scholaris Bark Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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