Is Aluminum Sulfate safe in cosmetics?
Aluminum Sulfate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 6 toxicological study endpoint(s) are available in our database.
Aluminum Sulfate
Also known as: Aluminum sulfate (3:2), Caswell No. 031A, Dialuminum sulphate, EINECS 233-135-0, EPA Pesticide Chemical Code 013906 (+13 more)
INCI: ALUMINUM SULFATE
Aluminum Sulfate (CAS 10043-01-3) is a cosmetic cosmetic ingredient functioning as Astringent. Reported NOAEL =40 mg/kg bw/day in Mouse (ECHA); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 10043-01-3 →
Cross-Vertical Regulatory Divergence
Aluminum Sulfate is classified GHS Danger (H290, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Astringent
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; also FDA GRAS for food use (water treatment, food additive). Not an approved OTC antiperspirant active.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aluminum Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Aluminum Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =40 mg/kg bw/day | injection | Mouse | reproduction developmental | ECHA |
| NOAEL | =300 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =317 mg/kg bw/day | oral | Rat | repeat dose other | ECHA |
| NOAEL | =342 mg/kg bw/day | oral | Rat | short-term | ECHA |
| NOAEL | =1850 mg/kg bw/day | oral | Rat | repeat dose other | ECHA |
| NOAEL | =10265 mg/kg bw/day | oral | Rat | subchronic | ECHA |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
Excl markWarn
Hazard Statements
Causes serious eye irritation May cause respiratory irritation Toxic to aquatic life
Short-term Exposure Effects
The substance is severely irritating to the eyes, respiratory tract and gastrointestinal tract. The substance is mildly irritating to the skin.
Long-term Exposure Effects
The substance may have effects on the central nervous system. This may result in impaired functions.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >5000 mg/kg | Rat | oral | - | EFSA |
| LD50 | >1167.5 mg/kg | Pig | dermal | short-term | ECHA |
| LD50 | >1167.5 mg/kg | Mouse | dermal | short-term | ECHA |
| LD50 | >5000 mg/kg | Rat | oral | - | ECHA |
| LD50 | =6200 mg/kg | Mouse | oral | - | ECHA |
| LD50 | =5 mg/kg | Rat | injection | - | ECHA |
| LEL | >233.5 mg/kg-day | Pig | dermal | short-term | ECHA |
| LEL | >233.5 mg/kg-day | Mouse | dermal | short-term | ECHA |
| LOAEL | =1250 mg/kg-day | Rat | oral | - | ECHA |
| LOAEL | =1500 mg/kg-day | Rat | oral | - | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antiperspirant
Astringent
Chelating agent
Deodorizer
Dye
Emulsifier
Processing aids not otherwise specified
Stabilizing agent
pH regulating agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Aluminum Sulfate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
endocrine_disruptor
fda_food_additive
jecfa_concern
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Aluminum Sulfate by CAS number or substance name.
Studies
6
Lowest NOAEL
40 mg/kg bw/day
Highest NOAEL
1.027e+4 mg/kg bw/day
ECHA
Known Synonyms
Aluminum sulfate (3:2)
Caswell No. 031A
Dialuminum sulphate
EINECS 233-135-0
EPA Pesticide Chemical Code 013906
Filter Alum
NSC 54563
Papermaker's Alum
Pearl Alum
Pickle Alum
Sulfuric acid, aluminum(3+) salt (3:2)
Aluminum(III) silfate
UNII-I7T908772F
Al2(SO4)3
alum
aluminium sesquisulfate
aluminium sulfate (2:3)
aluminium sulfate (anh.)
Chemical Function
Astringent
Deodorizer
Antiperspirant
pH regulating agent
Processing aids not otherwise specified
Chelating agent
Regulatory Lists
active_ingredient; Europe; Pesticides
active_ingredient; Europe; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ALUMINUM SULFATE ANHYDROUS
ChEMBL ID
CHEMBL3833402
Max Phase
-1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Aluminium sulfate
E Number
E520
ADI
1 mg/kg bw
Food Category
flavor_enhancer
Frequently Asked Questions
Is Aluminum Sulfate allowed in the EU?
Aluminum Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Aluminum Sulfate do in cosmetics?
Aluminum Sulfate functions as: Astringent. It is classified as a cosmetic ingredient in our database. CAS number: 10043-01-3.
What is the NOAEL for Aluminum Sulfate?
The NOAEL (No Observed Adverse Effect Level) for Aluminum Sulfate is =40 mg/kg bw/day based on a reproduction developmental study via injection route in Mouse. A total of 6 study endpoints are available. Source: ECHA.
Is Aluminum Sulfate classified as hazardous under GHS?
Aluminum Sulfate carries a GHS signal word of "WARNING". Hazard statements: Causes serious eye irritation May cause respiratory irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Aluminum Sulfate used outside cosmetics?
Aluminum Sulfate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Aluminum Sulfate have different safety status in cosmetics vs industrial chemicals?
Aluminum Sulfate is classified GHS Danger (H290, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Aluminum Sulfate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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