Is Ambrettolide safe in cosmetics?
Ambrettolide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Ambrettolide
Also known as: Oxacycloheptadec-7-en-2-one, 16-Hydroxy-6-hexadecenoic acid lactone, 1-Oxa-7-cycloheptadecen-2-one, oxacycloheptadec-7-ene-2-one, Oxacycloheptadec-7-en-2-on (+9 more)
INCI: AMBRETTOLIDE
Ambrettolide (CAS 7779-50-2) is a cosmetic cosmetic ingredient functioning as Fragrance, Masking. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 7779-50-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, Masking
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-oxacycloheptadec-7-en-2-one
InChIKey
HMWPDRYGIBLSHB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Used as fragrance ingredient; IFRA 51st Amendment imposes no quantitative restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ambrettolide.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 648 | - | - |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
fragrance
{"cas_number": "123-69-3", "ingredient_class": "synthetic_musk", "chemical_class": "macrocyclic", "odor_family": "musk", "odor_description": "Musk, amber, musky, floral", "odor_strength": "medium", "odor_tenacity_hours": "24.0", "top_note": "yes", "heart_note": "yes", "base_note": "no", "blending_factor_1_10": "7.0", "threshold_of_detection_ppb": "10.0", "molecular_weight_Da": "200.0", "boiling_po…
fragrance_ifra
{"cas_number": "123-69-3", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.17", "ifra_max_use_level_category_4_pct": "2.6", "ifra_max_use_level_category_7_pct": "0.40", "ifra_max_use_level_category_11_pct": "0.080", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Number
240
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Ambrettolide.
Regulatory Flags
fragrance
musk
macrocyclic
biodegradable
ifra_fragrance
fda_food_additive
Known Synonyms
Oxacycloheptadec-7-en-2-one
16-Hydroxy-6-hexadecenoic acid lactone
1-Oxa-7-cycloheptadecen-2-one
oxacycloheptadec-7-ene-2-one
Oxacycloheptadec-7-en-2-on
oxacicloheptadec-7-en-2-ona
Oxacycloheptadeca-7-en-2-one
CYCLOHEXADECEN-7-OLIDE
EINECS 231-929-1
6-Hexadecenlactone, omega-
6-Hexadecenolide
16-Hydroxy-6-hexadecenoic acid omega-lactone
delta6-Isoambrettolide
UNII-S79ZK47L2P
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Ambrettolide allowed in the EU?
Ambrettolide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ambrettolide do in cosmetics?
Ambrettolide functions as: Fragrance, Masking. It is classified as a cosmetic ingredient in our database. CAS number: 7779-50-2.
Is Ambrettolide used outside cosmetics?
Ambrettolide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ambrettolide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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