Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Ammonium Bisulfite. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 108 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 0.05 other | oral | rat | oral | REACH |
| NOAEL | 0.35 other | oral | pig | oral | REACH |
| NOAEL | 70 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 108 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >53 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Sulfite sensitivity risk in asthmatics; in vitro genotoxicity positives attributed to bisulfite form while sulfite form predominates in formulation and is non-genotoxic; mandatory labeling of sulfites required in some jurisdictions.
Regulatory Flags
Frequently Asked Questions
Is Ammonium Bisulfite safe in cosmetics?
Sulfite sensitivity risk in asthmatics; in vitro genotoxicity positives attributed to bisulfite form while sulfite form predominates in formulation and is non-genotoxic; mandatory labeling of sulfites required in some jurisdictions. The EU classifies Ammonium Bisulfite as "restricted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.
Is Ammonium Bisulfite allowed in the EU?
Ammonium Bisulfite EU regulatory status: restricted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Bisulfite do in cosmetics?
Ammonium Bisulfite functions as: Reducing agent for hair waving and straightening, antioxidant, preservative. It is classified as a cosmetic ingredient in our database. CAS number: 10192-30-0.
What is the Margin of Safety for Ammonium Bisulfite?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ammonium Bisulfite?
The NOAEL (No Observed Adverse Effect Level) for Ammonium Bisulfite is 108 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.
Is Ammonium Bisulfite classified as hazardous under GHS?
Ammonium Bisulfite carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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