Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Ammonium Fluoride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.1695.7 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | ca.4 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.25 ppm | oral | rat | oral | REACH |
| LOAEL | ca.100 ppm | oral | rat | oral | REACH |
| LOAEL | ca.25 ppm | oral | rat | oral | REACH |
| LOAEL | ca.50 ppm | oral | mouse | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Acute toxicity if ingested in excess; strictly oral care only; mandatory concentration and labeling restrictions in EU.
Regulatory Flags
Frequently Asked Questions
Is Ammonium Fluoride safe in cosmetics?
Acute toxicity if ingested in excess; strictly oral care only; mandatory concentration and labeling restrictions in EU. The EU classifies Ammonium Fluoride as "restricted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.
Is Ammonium Fluoride allowed in the EU?
Ammonium Fluoride EU regulatory status: restricted. Maximum allowed concentration: 0.15%. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Fluoride do in cosmetics?
Ammonium Fluoride functions as: Antiplaque agent; oral care (supports enamel remineralization). It is classified as a cosmetic ingredient in our database. CAS number: 12125-01-8.
What is the Margin of Safety for Ammonium Fluoride?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ammonium Fluoride?
The NOAEL (No Observed Adverse Effect Level) for Ammonium Fluoride is ca.1695.7 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
Check Ammonium Fluoride compliance across multiple jurisdictions:
Related Ingredients
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