Good Cosmetic Ingredient NOAEL Data

Amyl Butyrate

INCI: AMYL BUTYRATE

CAS Number
540-18-1
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no FDA restriction; FEMA GRAS for flavor use; falls under fragrance exemption

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Amyl Butyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Standard fragrance ingredient with low toxicity profile and established safe use in cosmetic applications.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Amyl Butyrate safe in cosmetics?

Standard fragrance ingredient with low toxicity profile and established safe use in cosmetic applications. The EU classifies Amyl Butyrate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Amyl Butyrate allowed in the EU?

Amyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Amyl Butyrate do in cosmetics?

Amyl Butyrate functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 540-18-1.

What is the Margin of Safety for Amyl Butyrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Amyl Butyrate?

The NOAEL (No Observed Adverse Effect Level) for Amyl Butyrate is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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