Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Cyclohexasiloxane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
EU Reg 2024/1328 (May 2024) restricted D6 in all consumer and professional products at ≥0.1% w/w, enforced June 6, 2026. ECHA SVHC since 2018 as vPvB. Unlike D4, not classified as reproductive toxicant. Projected to reduce emissions by up to 90% once enforcement is in place. Reformulation required for EU market. Linear volatile alternatives (caprylyl methicone, C13-15 alkanes) are the go-to replacements. Stockholm Convention POPs listing proposed.
Regulatory Flags
Frequently Asked Questions
Is Cyclohexasiloxane safe in cosmetics?
EU Reg 2024/1328 (May 2024) restricted D6 in all consumer and professional products at ≥0.1% w/w, enforced June 6, 2026. ECHA SVHC since 2018 as vPvB. Unlike D4, not classified as reproductive toxicant. Projected to reduce emissions by up to 90% once enforcement is in place. Reformulation required for EU market. Linear volatile alternatives (caprylyl methicone, C13-15 alkanes) are the go-to replacements. Stockholm Convention POPs listing proposed. The EU classifies Cyclohexasiloxane as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Cyclohexasiloxane allowed in the EU?
Cyclohexasiloxane EU regulatory status: restricted. Maximum allowed concentration: ≥0.1% w/w prohibited in all consumer and professional products under EU Reg 2024/1328; enforcement June 6, 2026. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclohexasiloxane do in cosmetics?
Cyclohexasiloxane functions as: solvent, emollient, volatile carrier. It is classified as a cosmetic ingredient in our database. CAS number: 540-97-6.
What is the Margin of Safety for Cyclohexasiloxane?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cyclohexasiloxane?
The NOAEL (No Observed Adverse Effect Level) for Cyclohexasiloxane is >=1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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