Is Cyclohexasiloxane safe in cosmetics?
Cyclohexasiloxane has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
MODERATE
Cosmetic Ingredient
Cyclohexasiloxane
Also known as: Cyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-, Cyclohexasiloxane, dodecamethyl-, 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane, EINECS 208-762-8, UNII-XHK3U310BA (+9 more)
INCI: CYCLOHEXASILOXANE
Cyclohexasiloxane (CAS 540-97-6) is a cosmetic cosmetic ingredient functioning as solvent, emollient, volatile carrier. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max ≥0.1% w/w prohibited in all consumer and professional products under EU Reg 2024/1328; enforcement June 6, 2026. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
Function
solvent, emollient, volatile carrier
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
EC Number
208-762-8
Regulatory Status
EU EU Status
restricted
EU Max Conc.
≥0.1% w/w prohibited in all consumer and professional products under EU Reg 2024/1328; enforcement June 6, 2026
US US Status
permitted
US Notes
No FDA restriction; no US restriction as of 2026
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclohexasiloxane.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Cyclohexasiloxane across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LEL | =545.922 mg/m3 | Rat | inhalation | short-term | EPA TSCA 8e |
| LD50 | >50000 mg/kg | Rat | oral | - | ChemIDplus |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα (weak)
LOEC: N/A
EU status: under_review
weak agonist
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 27-Jun-2018)
Hazard classification: Restricted (Annex XVII)
SVHC reason: PBT (Article 57d)
Substance of Very High Concern (SVHC)
Included: 27-Jun-2018
PBT (Article 57d); vPvB (Article 57e)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| UK | restricted | - | - |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Foundation | 2–10 | 20 | CIR Expert Panel |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Solvent
Editorial summary
Preliminary editorial summary for Cyclohexasiloxane — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
svhc
vpvb
eu-restricted-2026
reach-reg-2024-1328
bioaccumulative
environmental-hazard
volatile-silicone
cyclic-siloxane
pops-candidate
reformulate-required
Known Synonyms
Cyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-
Cyclohexasiloxane, dodecamethyl-
2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane
EINECS 208-762-8
UNII-XHK3U310BA
DC 246
DC 246 Fluid
Dow Corning 246
Dow Corning 246 Fluid
Hexadecamethylcyclohexasiloxane
SF 1258
SH 246
SH 246 Fluid
Xiameter PMX 0246
Chemical Function
Softener and conditioner
Solvent
Regulatory Lists
Europe; Other direct contact consumer goods
CEDI
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cyclohexasiloxane allowed in the EU?
Cyclohexasiloxane EU regulatory status: restricted. Maximum allowed concentration: ≥0.1% w/w prohibited in all consumer and professional products under EU Reg 2024/1328; enforcement June 6, 2026. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclohexasiloxane do in cosmetics?
Cyclohexasiloxane functions as: solvent, emollient, volatile carrier. It is classified as a cosmetic ingredient in our database. CAS number: 540-97-6.
Is Cyclohexasiloxane used outside cosmetics?
Cyclohexasiloxane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cyclohexasiloxane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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