Regulatory Status
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Safety Data
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Expert Verdict
Annonacin (acetogenin) is a mitochondrial complex I inhibitor linked to atypical parkinsonism via oral exposure; dermal relevance unclear but warrants supplier COA verification for acetogenin content
Regulatory Flags
Frequently Asked Questions
Is Annona Squamosa Seed Extract safe in cosmetics?
Annonacin (acetogenin) is a mitochondrial complex I inhibitor linked to atypical parkinsonism via oral exposure; dermal relevance unclear but warrants supplier COA verification for acetogenin content The EU classifies Annona Squamosa Seed Extract as "permitted". Safety rating: MODERATE.
Is Annona Squamosa Seed Extract allowed in the EU?
Annona Squamosa Seed Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Annona Squamosa Seed Extract do in cosmetics?
Annona Squamosa Seed Extract functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned in CosIng.
What is the Margin of Safety for Annona Squamosa Seed Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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