Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Aspartic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1100 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 1100 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1417 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 1100 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 1100 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Exceptionally safe amino acid with antistatic, hair- and skin-conditioning functions. No EU restrictions, US GRAS status, CIR-reviewed, and negligible dermal absorption due to high hydrophilicity. Ideal for conditioning hair and skin formulations with no regulatory burden.
Regulatory Flags
Frequently Asked Questions
Is Aspartic Acid safe in cosmetics?
Exceptionally safe amino acid with antistatic, hair- and skin-conditioning functions. No EU restrictions, US GRAS status, CIR-reviewed, and negligible dermal absorption due to high hydrophilicity. Ideal for conditioning hair and skin formulations with no regulatory burden. The EU classifies Aspartic Acid as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Aspartic Acid allowed in the EU?
Aspartic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Aspartic Acid do in cosmetics?
Aspartic Acid functions as: antistatic, hair conditioning, skin conditioning, fragrance. It is classified as a Humectant in our database. CAS number: 56-84-8.
What is the Margin of Safety for Aspartic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Aspartic Acid?
The NOAEL (No Observed Adverse Effect Level) for Aspartic Acid is 1100 mg/kg bw/day based on a Developmental study via oral route in rabbit. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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