Caprylyl Glycol
INCI: CAPRYLYL GLYCOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Caprylyl Glycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for Caprylyl Glycol based on clinical patch test studies and IFRA standards.
Source: ESSCA; IVDK; NACDG
Dermal Penetration Profile
Skin absorption and penetration characteristics of Caprylyl Glycol, relevant to systemic exposure and MoS calculations.
Source: Cosmetic Science
Expert Verdict
Multifunctional glycol with antimicrobial boosting and skin-conditioning properties. CIR-reviewed safe and popular preservative-booster in paraben-free systems at 0.3-1%.
Regulatory Flags
Frequently Asked Questions
Is Caprylyl Glycol safe in cosmetics?
Multifunctional glycol with antimicrobial boosting and skin-conditioning properties. CIR-reviewed safe and popular preservative-booster in paraben-free systems at 0.3-1%. The EU classifies Caprylyl Glycol as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Caprylyl Glycol allowed in the EU?
Caprylyl Glycol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Caprylyl Glycol do in cosmetics?
Caprylyl Glycol functions as: Humectant, skin conditioning agent, antimicrobial booster. It is classified as a Humectant in our database. CAS number: 1117-86-8.
What is the Margin of Safety for Caprylyl Glycol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Caprylyl Glycol?
The NOAEL (No Observed Adverse Effect Level) for Caprylyl Glycol is >150 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
Check Caprylyl Glycol compliance across multiple jurisdictions:
Related Ingredients
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