Regulatory Status
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Safety Data
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Dermal Penetration Profile
Skin absorption and penetration characteristics of Hydrolyzed Hyaluronic Acid, relevant to systemic exposure and MoS calculations.
Source: Int J Cosmet Sci 2017
Expert Verdict
Effective deep-penetrating humectant with demonstrated dermal delivery and collagen-stimulating activity via CD44 receptor interaction. 2 kDa form showed reduced crow's feet and improved collagen score in placebo-controlled trials. Slight caution for oligo-HA fractions due to theoretical pro-inflammatory TLR2/4 signaling at very low MW, addressed through formulation optimization. Overall safe and clinically effective.
Regulatory Flags
Frequently Asked Questions
Is Hydrolyzed Hyaluronic Acid safe in cosmetics?
Effective deep-penetrating humectant with demonstrated dermal delivery and collagen-stimulating activity via CD44 receptor interaction. 2 kDa form showed reduced crow's feet and improved collagen score in placebo-controlled trials. Slight caution for oligo-HA fractions due to theoretical pro-inflammatory TLR2/4 signaling at very low MW, addressed through formulation optimization. Overall safe and clinically effective. The EU classifies Hydrolyzed Hyaluronic Acid as "permitted". Safety rating: GOOD.
Is Hydrolyzed Hyaluronic Acid allowed in the EU?
Hydrolyzed Hyaluronic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrolyzed Hyaluronic Acid do in cosmetics?
Hydrolyzed Hyaluronic Acid functions as: Humectant, skin-conditioning, penetration-enhancing humectant. It is classified as a Humectant in our database. CAS number: 91078-65-8.
What is the Margin of Safety for Hydrolyzed Hyaluronic Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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