Is Basic Yellow 28 safe in cosmetics?
Basic Yellow 28 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Basic Yellow 28
Also known as: 3H-Indolium, 2-[[2-(4-methoxyphenyl)-2-methylhydrazinylidene]methyl]-1,3,3-trimethyl-, methyl sulfate (1:1), 3H-Indolium, 2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl-, methyl sulfate, EC No.: 258-946-7, Astrazon Golden Yellow GL, Astrazon Golden Yellow GL-E (+14 more)
INCI: BASIC YELLOW 28
Basic Yellow 28 (CAS 54060-92-3) is a cosmetic cosmetic ingredient functioning as Hair dyeing (semi-permanent cationic dye). Reported NOAEL =95 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 54060-92-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Basic Yellow 28 is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H312, H318, H330, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (semi-permanent cationic dye)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Exempt under coal-tar hair dye provision; caution labeling required
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Basic Yellow 28.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Basic Yellow 28. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =95 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1272
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1272
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Basic Yellow 28.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Basic Yellow 28 by CAS number or substance name.
Studies
2
Lowest NOAEL
95 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
3H-Indolium, 2-[[2-(4-methoxyphenyl)-2-methylhydrazinylidene]methyl]-1,3,3-trimethyl-, methyl sulfate (1:1)
3H-Indolium, 2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl-, methyl sulfate
EC No.: 258-946-7
Astrazon Golden Yellow GL
Astrazon Golden Yellow GL-E
Astrazon Golden Yellow GL-E 200
Astrazon Golden Yellow GL-FW
Basacryl Golden Yellow FD-X-GFL
Basacryl Golden Yellow X-GFL
Cationic Gold Yellow
Cationic Golden Yellow SD-GL
Cationic Golden Yellow X-GL
Coracryl Golden Yellow CGL
Crypur Golden Yellow GL
Diacryl Golden Yellow GL-N
Golden Yellow X-GL
Kayacryl Golden Yellow GL-ED
Lanaset Yellow 28
Maxilon Golden Yellow GL
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Basic Yellow 28 allowed in the EU?
Basic Yellow 28 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Basic Yellow 28 do in cosmetics?
Basic Yellow 28 functions as: Hair dyeing (semi-permanent cationic dye). It is classified as a cosmetic ingredient in our database. CAS number: 54060-92-3.
What is the NOAEL for Basic Yellow 28?
The NOAEL (No Observed Adverse Effect Level) for Basic Yellow 28 is =95 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Basic Yellow 28 used outside cosmetics?
Basic Yellow 28 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Basic Yellow 28 have different safety status in cosmetics vs industrial chemicals?
Basic Yellow 28 is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H302, H312, H318, H330, H400, H410).
Compliance Tools
Check Basic Yellow 28 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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