Moderate Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

Basic Yellow 87

INCI: BASIC YELLOW 87

CAS Number
68259-00-7
Function
Hair dyeing; used at 0.2% in semi-permanent and 0.1% final concentration in oxidative formulations
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Exempt under coal-tar hair dye provision

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Basic Yellow 87. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 10 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 50 mg/kg bw/day oral rat Subchronic COSMOS_DB

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir March 31, 2023
Verdict: safe
NOAEL: 0.676 mg/kg bw/d (oral)

ata to determine the safety of this ingredient. The Panel concluded that Basic Yellow 87 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. INTRODUCTION Basic Yellow 87 is reported to function as a hair colorant in c

cir March 31, 2023
Verdict: safe
NOAEL: 174 mg/kg bw/d (oral)

ata to determine the safety of this ingredient. The Panel concluded that Basic Yellow 87 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. INTRODUCTION Basic Yellow 87 is reported to function as a hair colorant in c

cir March 31, 2023
Verdict: safe
NOAEL: 10 mg/kg bw/d (oral)

ata to determine the safety of this ingredient. The Panel concluded that Basic Yellow 87 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. INTRODUCTION Basic Yellow 87 is reported to function as a hair colorant in c

cir March 31, 2023
Verdict: safe
NOAEL: 60 mg/kg bw/d (not specified)

ata to determine the safety of this ingredient. The Panel concluded that Basic Yellow 87 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. INTRODUCTION Basic Yellow 87 is reported to function as a hair colorant in c

cir March 31, 2023
Verdict: safe
NOAEL: 60 mg/kg bw/d (oral)

ata to determine the safety of this ingredient. The Panel concluded that Basic Yellow 87 is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment. INTRODUCTION Basic Yellow 87 is reported to function as a hair colorant in c

Expert Verdict

Phototoxic at concentrations โ‰ฅ25% (not at 15%); not photoallergenic; moderately irritating to eyes; some methodological concerns in in vitro genotoxicity with inconclusive chromosomal aberration test; oral LD50 500โ€“1000 mg/kg in female rats.

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Concern Level: High

Regulatory Flags

potential-allergen eu_children_restricted eu_cosing_listed

Frequently Asked Questions

Is Basic Yellow 87 safe in cosmetics?

Phototoxic at concentrations โ‰ฅ25% (not at 15%); not photoallergenic; moderately irritating to eyes; some methodological concerns in in vitro genotoxicity with inconclusive chromosomal aberration test; oral LD50 500โ€“1000 mg/kg in female rats. The EU classifies Basic Yellow 87 as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is Basic Yellow 87 allowed in the EU?

Basic Yellow 87 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Basic Yellow 87 do in cosmetics?

Basic Yellow 87 functions as: Hair dyeing; used at 0.2% in semi-permanent and 0.1% final concentration in oxidative formulations. It is classified as a cosmetic ingredient in our database. CAS number: 68259-00-7.

What is the Margin of Safety for Basic Yellow 87?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Basic Yellow 87?

The NOAEL (No Observed Adverse Effect Level) for Basic Yellow 87 is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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