Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide

INCI: BIS-RETINOYL GEROTINE BIS-HYDROXYSUCCINIMIDE

CAS Number
Not assigned / not publicly available
Function
Skin conditioning (retinoid peptide conjugate)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No CIR review; no FDA-specific restriction beyond general retinoid safety

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Critical data gap โ€” no public safety dossier. Must obtain supplier NOAEL/MoS data. EU Annex III retinoid limits apply. Formulator must independently calculate Retinol Equivalent (RE).

โš ๏ธ
Concern Level: Moderate

Frequently Asked Questions

Is Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide safe in cosmetics?

Critical data gap โ€” no public safety dossier. Must obtain supplier NOAEL/MoS data. EU Annex III retinoid limits apply. Formulator must independently calculate Retinol Equivalent (RE). The EU classifies Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide as "restricted". Safety rating: MODERATE.

Is Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide allowed in the EU?

Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide do in cosmetics?

Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide functions as: Skin conditioning (retinoid peptide conjugate). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned / not publicly available.

What is the Margin of Safety for Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Bis-Retinoyl Gerotine Bis-Hydroxysuccinimide in your formulation.