Boronophenylalanine HCl

INCI: BORONOPHENYLALANINE HCL

CAS Number
91196-68-8 (DL-form HCl); 74611-70-4 (B-10 enriched HCl); base BPA: 76410-58-7
Function
Not intended for cosmetic use; pharmaceutical boron delivery agent for Boron Neutron Capture Therapy (BNCT)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not reviewed by CIR for cosmetic use; FDA regulates as investigational drug/medical agent. Must not be formulated into cosmetic products.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

This is a pharmaceutical/oncology agent, not a cosmetic ingredient. Causes skin irritation, serious eye irritation, and respiratory irritation (GHS H315, H319, H335). Must not be formulated into any cosmetic product. If encountered in a cosmetic ingredient database, it represents a cataloguing artifact, not a use authorization.

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Concern Level: High

Frequently Asked Questions

Is Boronophenylalanine HCl safe in cosmetics?

This is a pharmaceutical/oncology agent, not a cosmetic ingredient. Causes skin irritation, serious eye irritation, and respiratory irritation (GHS H315, H319, H335). Must not be formulated into any cosmetic product. If encountered in a cosmetic ingredient database, it represents a cataloguing artifact, not a use authorization. The EU classifies Boronophenylalanine HCl as "prohibited". Safety rating: POOR.

Is Boronophenylalanine HCl allowed in the EU?

Boronophenylalanine HCl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Boronophenylalanine HCl do in cosmetics?

Boronophenylalanine HCl functions as: Not intended for cosmetic use; pharmaceutical boron delivery agent for Boron Neutron Capture Therapy (BNCT). It is classified as a cosmetic ingredient in our database. CAS number: 91196-68-8 (DL-form HCl); 74611-70-4 (B-10 enriched HCl); base BPA: 76410-58-7.

What is the Margin of Safety for Boronophenylalanine HCl?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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