Is Butyl Isobutyrate safe in cosmetics?
Butyl Isobutyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Butyl Isobutyrate
Also known as: Butyl isobutanoate, Butyl 2-methylpropanoate, EINECS 202-614-6, FEMA No. 2188, UNII-PW9UJ5C0F3
INCI: BUTYL ISOBUTYRATE
Butyl Isobutyrate (CAS 97-87-0) is a cosmetic cosmetic ingredient functioning as Fragrance / Masking agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 97-87-0 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / Masking agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
butyl 2-methylpropanoate
InChIKey
JSLCOZYBKYHZNL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
RIFM-type quantitative risk assessment (QRA) applicable. Favorable MoS expected at typical fragrance-level concentrations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2592 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [128] Kligman AM (1974): Report to RIFM, 22 August, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
188
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYL ISOBUTYRATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/267
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Isobutyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Butyl isobutanoate
Butyl 2-methylpropanoate
EINECS 202-614-6
FEMA No. 2188
UNII-PW9UJ5C0F3
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Butyl Isobutyrate allowed in the EU?
Butyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Isobutyrate do in cosmetics?
Butyl Isobutyrate functions as: Fragrance / Masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 97-87-0.
Is Butyl Isobutyrate used outside cosmetics?
Butyl Isobutyrate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Butyl Isobutyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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