Good Cosmetic Ingredient NOAEL Data

Butyl Laevulinate

INCI: BUTYL LAEVULINATE

CAS Number
2052-15-5
Function
Fragrance, Solvent, Masking agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Likely favorable โ€” read-across from levulinic acid and butanol toxicological profiles. Standalone MoS calculation not published.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Butyl Laevulinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 125 mg/kg bw/day oral rat oral REACH

Expert Verdict

Limited cosmetic-specific toxicological data; safety supported by read-across from levulinic acid and butanol profiles with FEMA GRAS status.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Butyl Laevulinate safe in cosmetics?

Limited cosmetic-specific toxicological data; safety supported by read-across from levulinic acid and butanol profiles with FEMA GRAS status. The EU classifies Butyl Laevulinate as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Butyl Laevulinate allowed in the EU?

Butyl Laevulinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Butyl Laevulinate do in cosmetics?

Butyl Laevulinate functions as: Fragrance, Solvent, Masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 2052-15-5.

What is the Margin of Safety for Butyl Laevulinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Butyl Laevulinate?

The NOAEL (No Observed Adverse Effect Level) for Butyl Laevulinate is 125 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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