Is Butylidenephthalide safe in cosmetics?
Butylidenephthalide has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Butylidenephthalide
INCI: BUTYLIDENEPHTHALIDE
Butylidenephthalide (CAS 551-08-6 (mixture/racemic); 76681-73-7 (E-isomer)) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 551-08-6 (mixture/racemic); 76681-73-7 (E-isomer) →
Auto-generated CPSR Part A draft with source citations
CAS Number
551-08-6 (mixture/racemic); 76681-73-7 (E-isomer)
View industrial chemical safety profile →
Function
Fragrance ingredient
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Needs ingredient-specific MoS calculation — limited published dermal toxicity data for cosmetic exposure scenarios
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butylidenephthalide.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Butylidenephthalide.
Regulatory Flags
fragrance-component
natural-origin
Frequently Asked Questions
Is Butylidenephthalide allowed in the EU?
Butylidenephthalide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Butylidenephthalide do in cosmetics?
Butylidenephthalide functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 551-08-6 (mixture/racemic); 76681-73-7 (E-isomer).
Compliance Tools
Check Butylidenephthalide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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