Butylidenephthalide

INCI: BUTYLIDENEPHTHALIDE

CAS Number
551-08-6 (mixture/racemic); 76681-73-7 (E-isomer)
Function
Fragrance ingredient
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Needs ingredient-specific MoS calculation โ€” limited published dermal toxicity data for cosmetic exposure scenarios

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Irritant classification; naturally occurs in Angelica sinensis and celery oils; verify concentration in final product against IFRA guidelines

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Concern Level: Moderate

Regulatory Flags

fragrance-component natural-origin

Frequently Asked Questions

Is Butylidenephthalide safe in cosmetics?

Irritant classification; naturally occurs in Angelica sinensis and celery oils; verify concentration in final product against IFRA guidelines The EU classifies Butylidenephthalide as "prohibited". Safety rating: MODERATE.

Is Butylidenephthalide allowed in the EU?

Butylidenephthalide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Butylidenephthalide do in cosmetics?

Butylidenephthalide functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 551-08-6 (mixture/racemic); 76681-73-7 (E-isomer).

What is the Margin of Safety for Butylidenephthalide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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