Butylphthalide

INCI: BUTYLPHTHALIDE

CAS Number
6066-49-5 (3-n-Butylphthalide)
Function
Fragrance (naturally occurring in celery seed oil)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Insufficient data. No cosmetic-specific margin of safety calculation published.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Structurally a phthalide (not a phthalate), but the name may trigger regulatory scrutiny. Limited dermal safety data for cosmetic use; cosmetic safety assessor will likely require supporting toxicological read-across data.

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Concern Level: Moderate

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is Butylphthalide safe in cosmetics?

Structurally a phthalide (not a phthalate), but the name may trigger regulatory scrutiny. Limited dermal safety data for cosmetic use; cosmetic safety assessor will likely require supporting toxicological read-across data. The EU classifies Butylphthalide as "prohibited". Safety rating: MODERATE.

Is Butylphthalide allowed in the EU?

Butylphthalide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Butylphthalide do in cosmetics?

Butylphthalide functions as: Fragrance (naturally occurring in celery seed oil). It is classified as a cosmetic ingredient in our database. CAS number: 6066-49-5 (3-n-Butylphthalide).

What is the Margin of Safety for Butylphthalide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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