Butyroyl SH-Pentapeptide-12 SP

INCI: BUTYROYL SH-PENTAPEPTIDE-12 SP

CAS Number
Not assigned (novel synthetic peptide)
Function
Skin Conditioning – Miscellaneous (anti-aging peptide)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not established — no NOAEL data available

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel synthetic peptide with no CIR review. Thiol (SH) group may raise oxidative stability questions. Supplier certificate of analysis and safety dossier mandatory. Near 0% market penetration with limited prevalence data.

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Concern Level: Moderate

Frequently Asked Questions

Is Butyroyl SH-Pentapeptide-12 SP safe in cosmetics?

Novel synthetic peptide with no CIR review. Thiol (SH) group may raise oxidative stability questions. Supplier certificate of analysis and safety dossier mandatory. Near 0% market penetration with limited prevalence data. The EU classifies Butyroyl SH-Pentapeptide-12 SP as "permitted". Safety rating: MODERATE.

Is Butyroyl SH-Pentapeptide-12 SP allowed in the EU?

Butyroyl SH-Pentapeptide-12 SP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Butyroyl SH-Pentapeptide-12 SP do in cosmetics?

Butyroyl SH-Pentapeptide-12 SP functions as: Skin Conditioning – Miscellaneous (anti-aging peptide). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (novel synthetic peptide).

What is the Margin of Safety for Butyroyl SH-Pentapeptide-12 SP?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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