Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Calcium Benzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 3571 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 905 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 2620 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | cat | oral | REACH |
| NOAEL | 648 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Preservative with restricted use; must not exceed 2.5% concentration per Annex V; potential to form benzene when combined with ascorbic acid under certain conditions; pH-dependent efficacy with optimal performance below pH 5.
Regulatory Flags
Frequently Asked Questions
Is Calcium Benzoate safe in cosmetics?
Preservative with restricted use; must not exceed 2.5% concentration per Annex V; potential to form benzene when combined with ascorbic acid under certain conditions; pH-dependent efficacy with optimal performance below pH 5. The EU classifies Calcium Benzoate as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Calcium Benzoate allowed in the EU?
Calcium Benzoate EU regulatory status: restricted. Maximum allowed concentration: 2.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Benzoate do in cosmetics?
Calcium Benzoate functions as: Preservative. It is classified as a cosmetic ingredient in our database. CAS number: 2090-05-3.
What is the Margin of Safety for Calcium Benzoate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Benzoate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Benzoate is 300 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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