Is Calcium Hydroxyapatite safe in cosmetics?
Calcium Hydroxyapatite has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by sccs.
Calcium Hydroxyapatite
Also known as: Apatite hydroxide (Ca10(PO4)6(OH)2), Hydroxypol, EINECS No.: 215-145-7, Hydroxylapatite, Cellyard-AX (+7 more)
INCI: HYDROXYAPATITE
Calcium Hydroxyapatite (CAS 1306-06-5) is a cosmetic cosmetic ingredient functioning as Abrasive, bulking agent, oral care, skin conditioning. EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1306-06-5 →
Auto-generated CPSR Part A draft with source citations
Function
Abrasive, bulking agent, oral care, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
215-145-7
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Adequate for non-nano dermal use; insufficient data for nano form MoS calculation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Hydroxyapatite.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
sccs
SCCS/1677/25
26 June 2025
Verdict: safe
Max Concentration: 29.5% in oral care
osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut
sccs
SCCS/1677/25
26 June 2025
Verdict: safe
Max Concentration: 10% in oral care
osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut
sccs
SCCS/1677/25
26 June 2025
Verdict: safe
Max Concentration: 0.465% in oral care
osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut
sccs
SCCS/1648/22
22 March 2023
Verdict: safe
Max Concentration: 10% in oral care
posure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 10% in toothpaste, and up to 0.465% in mouthwash. This safety evaluation only applies to the hydroxyapatite (nano) with the following characteristics: - compo
sccs
SCCS/1648/22
22 March 2023
Verdict: safe
Max Concentration: 0.465% in oral care
posure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 10% in toothpaste, and up to 0.465% in mouthwash. This safety evaluation only applies to the hydroxyapatite (nano) with the following characteristics: - compo
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| UK | restricted | - | - |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
mineral_clay
{"cas_number": "1306-06-5", "ingredient_class": "calcium_compound", "chemical_formula": "Ca10(PO4)6(OH)2", "mineral_origin": "synthetic", "particle_size_range_um": "0.02-5", "surface_area_m2_per_g": "50-200", "crystal_structure": "hexagonal", "color_appearance": "white", "opacity": "opaque", "refractive_index": "1.65", "oil_absorption_g_per_100g": "40-80", "water_absorption_capacity": "30-60%", "s…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Filler
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Hydroxyapatite.
Known Synonyms
Apatite hydroxide (Ca10(PO4)6(OH)2)
Hydroxypol
EINECS No.: 215-145-7
Hydroxylapatite
Cellyard-AX
Coralina HAP 200
Boneceram P-G 1
Bone ject
Captal 60-1
HAP 100 (mineral)
Micro-SHAp IHM 100P000
Calcium hydroxyphosphate
Chemical Function
Abrasive
Softener and conditioner
Filler
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DURAPATITE
ChEMBL ID
CHEMBL2218916
Max Phase
2
Adverse Event Associations
1
Frequently Asked Questions
Is Calcium Hydroxyapatite allowed in the EU?
Calcium Hydroxyapatite EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Hydroxyapatite do in cosmetics?
Calcium Hydroxyapatite functions as: Abrasive, bulking agent, oral care, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 1306-06-5.
Is Calcium Hydroxyapatite used outside cosmetics?
Calcium Hydroxyapatite also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Hydroxyapatite compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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