Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut
osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut
osure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 29.5% in toothpaste, and up to 10% in mouthwash. This conclusion is based on the available evidence, which shows that hydroxyapatite (nano) does not pose a mut
posure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 10% in toothpaste, and up to 0.465% in mouthwash. This safety evaluation only applies to the hydroxyapatite (nano) with the following characteristics: - compo
posure conditions? Based on the data provided, the SCCS considers hydroxyapatite (nano) safe when used at concentrations up to 10% in toothpaste, and up to 0.465% in mouthwash. This safety evaluation only applies to the hydroxyapatite (nano) with the following characteristics: - compo
Expert Verdict
Calcium phosphate mineral naturally present in bone and tooth enamel with long-established safe use in oral care; however, nano-form is prohibited in EU cosmetics effective February 2025 under Commission Regulation (EU) 2024/858 due to insufficient safety evidence, requiring immediate compliance action for EU-marketed products.
Regulatory Flags
Frequently Asked Questions
Is Hydroxyapatite safe in cosmetics?
Calcium phosphate mineral naturally present in bone and tooth enamel with long-established safe use in oral care; however, nano-form is prohibited in EU cosmetics effective February 2025 under Commission Regulation (EU) 2024/858 due to insufficient safety evidence, requiring immediate compliance action for EU-marketed products. The EU classifies Hydroxyapatite as "restricted". Safety rating: MODERATE. This ingredient has been reviewed by sccs.
Is Hydroxyapatite allowed in the EU?
Hydroxyapatite EU regulatory status: restricted. Maximum allowed concentration: Non-nano conventional hydroxyapatite permitted in cosmetics (e.g., oral care). Nano-form prohibited in cosmetics effective February 2025 per Commission Regulation (EU) 2024/858. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyapatite do in cosmetics?
Hydroxyapatite functions as: Abrasive; oral care active; whitening; bulking agent; structuring agent; nano-form was investigated as skin delivery carrier. It is classified as a Cosmetic Ingredient in our database. CAS number: 1306-06-5.
What is the Margin of Safety for Hydroxyapatite?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Hydroxyapatite compliance across multiple jurisdictions:
Related Ingredients
Is Hydroxyapatite in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hydroxyapatite in your formulation.