Calcium Hydroxymethylbutyrate

INCI: CALCIUM HYDROXYMETHYLBUTYRATE

CAS Number
135236-72-5
Function
Skin conditioning (calcium salt of β-hydroxy-β-methylbutyric acid / HMB-Ca)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Oral NOAEL available (~400 mg/kg/day); dermal MoS calculable but not published

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Primarily a nutraceutical ingredient with limited cosmetic use history. Formulator should document intended function and justify use in CPSR.

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Concern Level: Low

Frequently Asked Questions

Is Calcium Hydroxymethylbutyrate safe in cosmetics?

Primarily a nutraceutical ingredient with limited cosmetic use history. Formulator should document intended function and justify use in CPSR. The EU classifies Calcium Hydroxymethylbutyrate as "permitted". Safety rating: GOOD.

Is Calcium Hydroxymethylbutyrate allowed in the EU?

Calcium Hydroxymethylbutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Calcium Hydroxymethylbutyrate do in cosmetics?

Calcium Hydroxymethylbutyrate functions as: Skin conditioning (calcium salt of β-hydroxy-β-methylbutyric acid / HMB-Ca). It is classified as a cosmetic ingredient in our database. CAS number: 135236-72-5.

What is the Margin of Safety for Calcium Hydroxymethylbutyrate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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