Is Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) safe in cosmetics?
Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Active Ingredient
Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract)
Also known as: Dextran 40,70,110, Dextranum 40,70, EINECS 232-677-5, Low molecular dextran-L, Polyglucinum (+15 more)
INCI: CAPIXYL
Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) (CAS 9004-54-0) is a cosmetic active ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
Function
Antioxidant
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No monograph exists
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract).
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
KeratinoSens IC50
2000 µM
GHS: inconclusive
Source: KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Filler
Processing aids not otherwise specified
Surface modifier
Thickening agent
Viscosity modifier
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fda_food_additive
Known Synonyms
Dextran 40,70,110
Dextranum 40,70
EINECS 232-677-5
Low molecular dextran-L
Polyglucinum
Dextranum
UNII-7SA290YK68
UNII-K3R6ZDH4DU
UNII-ZNJ8R24I7Z
UNII-65DL069QBP
UNII-21C3YS80Q6
UNII-42N66Q2197
UNII-PD6VU01UVN
UNII-V7031C06AY
UNII-E8A73H7RG1
UNII-05Q25F6XJ3
UNII-P8272ET3N5
UNII-41Z0077J45
UNII-7C8S056150
UNII-B854H05S7D
Chemical Function
Viscosity modifier
Binder
Filler
Processing aids not otherwise specified
Thickening agent
Surface modifier
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
DEXTRANS (AVG M W LESS THAN 100,000)
Food Category
thickener
Frequently Asked Questions
Is Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) allowed in the EU?
Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) do in cosmetics?
Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) functions as: Antioxidant. It is classified as a Active Ingredient in our database. CAS number: 9004-54-0.
Is Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) used outside cosmetics?
Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acetyl Tetrapeptide-5
EXCELLENT
Same category
Anti-edema peptide for periorbital ar...
Activated Charcoal
EXCELLENT
Same category
Adsorbent; skin cleanser; pore-cleans...
Adenosine
EXCELLENT
Same category
Skin-conditioning agent, anti-aging, ...
Allantoin
EXCELLENT
Same category
Skin conditioner, keratolytic, anti-i...
Alpha-Glucan Oligosaccharide
EXCELLENT
Same category
prebiotic, skin-conditioning
Ascophyllum Nodosum Extract
EXCELLENT
Same category
Skin Brightening, Tyrosinase Inhibito...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
GOOD
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
GOOD
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
GOOD
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
GOOD
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
GOOD
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
GOOD
Similar safety
Antioxidant
C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate
GOOD
Chemical family
Skin conditioning, humectant, moistur...
CETETH-10
GOOD
Chemical family
Surfactant - Cleansing, Surfactant - ...
CETETH-2
GOOD
Chemical family
Surfactant - Emulsifying
Is Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) in your formulation.