Good Active Ingredient NOAEL Data

Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract)

INCI: CAPIXYL

CAS Number
9004-54-0
Function
Antioxidant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No monograph exists

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 15000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 15000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Good safety profile. Generally considered safe for cosmetic use.

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Concern Level: Low

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) safe in cosmetics?

Good safety profile. Generally considered safe for cosmetic use. The EU classifies Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) allowed in the EU?

Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) do in cosmetics?

Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) functions as: Antioxidant. It is classified as a Active Ingredient in our database. CAS number: 9004-54-0.

What is the Margin of Safety for Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract)?

The NOAEL (No Observed Adverse Effect Level) for Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) is 15000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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