Good Active Ingredient

Phytonadione

INCI: PHYTONADIONE

CAS Number
84-80-0
Function
Skin-conditioning agent; coagulation cascade cofactor (vitamin K1); vascular integrity support; anti-bruising; periorbital dark circle treatment; anti-inflammatory; post-procedural recovery
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA concentration limits for topical cosmetic use. Classified as cosmetic ingredient for periorbital and bruising applications. Vitamin K as anticoagulant reversal agent is a pharmaceutical; topical cosmetic use at low concentrations for appearance purposes does not trigger drug classification under FDA guidance.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Vitamin K1 (phytonadione) is the best-evidenced cosmetic form of vitamin K for periorbital applications, with clinical studies confirming efficacy for vascular dark circles and ecchymosis resolution through coagulation cascade support and vascular integrity enhancement. Formulators should monitor for upcoming EU regulatory changes regarding phytonadione epoxide (oxidation product) with May 2026 submission deadline.

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Concern Level: Low

Regulatory Flags

vitamin-k1 periorbital dark-circles anti-bruising anti-inflammatory rosacea-adjunct post-procedural vascular-integrity eu-call-for-data-epoxide-2026 small-rct-only lipid-soluble low-concentration-effective

Frequently Asked Questions

Is Phytonadione safe in cosmetics?

Vitamin K1 (phytonadione) is the best-evidenced cosmetic form of vitamin K for periorbital applications, with clinical studies confirming efficacy for vascular dark circles and ecchymosis resolution through coagulation cascade support and vascular integrity enhancement. Formulators should monitor for upcoming EU regulatory changes regarding phytonadione epoxide (oxidation product) with May 2026 submission deadline. The EU classifies Phytonadione as "permitted". Safety rating: GOOD.

Is Phytonadione allowed in the EU?

Phytonadione EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Phytonadione do in cosmetics?

Phytonadione functions as: Skin-conditioning agent; coagulation cascade cofactor (vitamin K1); vascular integrity support; anti-bruising; periorbital dark circle treatment; anti-inflammatory; post-procedural recovery. It is classified as a Active Ingredient in our database. CAS number: 84-80-0.

What is the Margin of Safety for Phytonadione?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Phytonadione compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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