Is Phytonadione safe in cosmetics?
Phytonadione has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Phytonadione
Also known as: Phylloquinone, K1, EINECS 201-564-2, 1,4-Naphthoquinone, 2-methyl-3-phytyl-, UNII-S5Z3U87QHF, 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione (+15 more)
INCI: PHYTONADIONE
Phytonadione (CAS 84-80-0) is a cosmetic active ingredient functioning as Skin-conditioning agent; coagulation cascade cofactor (vitamin K1); vascular. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 84-80-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning agent; coagulation cascade cofactor (vitamin K1); vascular integrity support; anti-bruising; periorbital dark circle treatment; anti-inflammatory; post-procedural recovery
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
InChIKey
MBWXNTAXLNYFJB-NKFFZRIASA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA concentration limits for topical cosmetic use. Classified as cosmetic ingredient for periorbital and bruising applications. Vitamin K as anticoagulant reversal agent is a pharmaceutical; topical cosmetic use at low concentrations for appearance purposes does not trigger drug classification under FDA guidance.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phytonadione.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =25000 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | >33487 mg/kg | Rat | oral | - | ChemIDplus |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of vitamin K. There is inadequate evidence in experimental animals for the carcinogenicity of vitamin K. Overall evaluation: Vitamin K is not classifiable as to its carcinogenicity to humans (Group 3). /Vitamin K/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Phytonadione.
Regulatory Flags
vitamin-k1
periorbital
dark-circles
anti-bruising
anti-inflammatory
rosacea-adjunct
post-procedural
vascular-integrity
eu-call-for-data-epoxide-2026
small-rct-only
lipid-soluble
low-concentration-effective
Known Synonyms
Phylloquinone, K1
EINECS 201-564-2
1,4-Naphthoquinone, 2-methyl-3-phytyl-
UNII-S5Z3U87QHF
2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione
2-Methyl-3-phythyl-1,4-naphthochinon
2-Methyl-3-phytyl-1,4-naphthochinon
2-Methyl-3-phytyl-1,4-napthoquinone
2-methyl-3-[(2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione
3-Phytylmenadione
Aqua Mephyton
Aqua-Mephytin
Fitomenadione
K-Ject
Phyllochinon
Phyllochinonum
Phythyl-menadion
Phytomenadionum
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PHYTONADIONE
ChEMBL ID
CHEMBL1550
Max Phase
4
Adverse Event Associations
161
Frequently Asked Questions
Is Phytonadione allowed in the EU?
Phytonadione EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phytonadione do in cosmetics?
Phytonadione functions as: Skin-conditioning agent; coagulation cascade cofactor (vitamin K1); vascular integrity support; anti-bruising; periorbital dark circle treatment; anti-inflammatory; post-procedural recovery. It is classified as a Active Ingredient in our database. CAS number: 84-80-0.
Is Phytonadione used outside cosmetics?
Phytonadione also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phytonadione compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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