Good Cosmetic Ingredient NOAEL Data

Caprylyl Caprylate/Caprate

INCI: CAPRYLYL CAPRYLATE/CAPRATE

CAS Number
N/A
Function
Emollient, skin conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR safe as used in alkyl esters group (239 ingredients). 11 VCRP uses documented for caprylyl caprylate component. CIR notes potential penetration enhancement; formulate to ensure non-irritating.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

7 study endpoints found for Caprylyl Caprylate/Caprate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 30 mg/kg bw/day dermal - - SCCS_PDF_extraction
NOAEL 30 mg/kg bw/day - - reproductive SCCS_PDF_extraction
NOAEL 30 mg/kg bw/day oral rat reproductive SCCS_PDF_extraction
NOAEL 30 mg/kg bw/day oral - reproductive SCCS_PDF_extraction
NOAEL 30 mg/kg bw/day dermal - - SCCS_PDF_extraction
NOAEL 30 mg/kg bw/day oral - reproductive SCCS_PDF_extraction
NOAEL 30 mg/kg bw/day - - reproductive SCCS_PDF_extraction

Expert Verdict

CIR-assessed safe as used in alkyl esters group with clean safety profile; low irritation risk when formulated appropriately.

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Concern Level: Low

Regulatory Flags

PENETRATION_ENHANCER

Frequently Asked Questions

Is Caprylyl Caprylate/Caprate safe in cosmetics?

CIR-assessed safe as used in alkyl esters group with clean safety profile; low irritation risk when formulated appropriately. The EU classifies Caprylyl Caprylate/Caprate as "permitted". Safety rating: GOOD. 7 toxicological study endpoint(s) are available in our database.

Is Caprylyl Caprylate/Caprate allowed in the EU?

Caprylyl Caprylate/Caprate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Caprylyl Caprylate/Caprate do in cosmetics?

Caprylyl Caprylate/Caprate functions as: Emollient, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: N/A.

What is the Margin of Safety for Caprylyl Caprylate/Caprate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Caprylyl Caprylate/Caprate?

The NOAEL (No Observed Adverse Effect Level) for Caprylyl Caprylate/Caprate is 30 mg/kg bw/day based on a toxicological study via dermal route in rat. A total of 7 study endpoints are available. Source: SCCS_PDF_extraction.

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