Moderate Cosmetic Ingredient Sensitization Data

Carvone

INCI: CARVONE

CAS Number
99-49-0 (racemic); 6485-40-1 (l-carvone); 2244-16-8 (d-carvone)
Function
Perfuming, denaturant, fragrance allergen
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes GRAS (21 CFR 182.60; FEMA 2249)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Carvone based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS/1459/11

Expert Verdict

Carvone is a naturally occurring fragrance compound with low absorption and sensitization potential, though it is recognized as a fragrance allergen and its margin of safety has not been established.

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Concern Level: Moderate

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is Carvone safe in cosmetics?

Carvone is a naturally occurring fragrance compound with low absorption and sensitization potential, though it is recognized as a fragrance allergen and its margin of safety has not been established. The EU classifies Carvone as "permitted". Safety rating: MODERATE.

Is Carvone allowed in the EU?

Carvone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Carvone do in cosmetics?

Carvone functions as: Perfuming, denaturant, fragrance allergen. It is classified as a cosmetic ingredient in our database. CAS number: 99-49-0 (racemic); 6485-40-1 (l-carvone); 2244-16-8 (d-carvone).

What is the Margin of Safety for Carvone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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