Moderate Cosmetic Ingredient NOAEL Data

Cetyl Betaine

INCI: CETYL BETAINE

CAS Number
693-33-4
Function
Antistatic, Hair Conditioning, Skin Conditioning, Surfactant-Cleansing, Foam Boosting, Viscosity Increasing
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; CIR: safe as used when formulated to be non-irritating (alkyl betaines final report, 2014)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Cetyl Betaine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 350 mg/kg bw/day oral rat oral REACH
NOAEL 500 mg/kg bw/day oral rat oral REACH
NOAEL 250 mg/kg bw/day oral rat oral REACH

Expert Verdict

Must formulate to be non-irritating; decreases skin barrier function in vitro; typical surfactant-class irritation potential at elevated concentrations; ocular irritant potential noted for related alkyl betaines

⚠️
Concern Level: Moderate

Regulatory Flags

eu_children_restricted epa_safer_alternative

Frequently Asked Questions

Is Cetyl Betaine safe in cosmetics?

Must formulate to be non-irritating; decreases skin barrier function in vitro; typical surfactant-class irritation potential at elevated concentrations; ocular irritant potential noted for related alkyl betaines The EU classifies Cetyl Betaine as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.

Is Cetyl Betaine allowed in the EU?

Cetyl Betaine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cetyl Betaine do in cosmetics?

Cetyl Betaine functions as: Antistatic, Hair Conditioning, Skin Conditioning, Surfactant-Cleansing, Foam Boosting, Viscosity Increasing. It is classified as a cosmetic ingredient in our database. CAS number: 693-33-4.

What is the Margin of Safety for Cetyl Betaine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Cetyl Betaine?

The NOAEL (No Observed Adverse Effect Level) for Cetyl Betaine is 350 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

Compliance Tools

Check Cetyl Betaine compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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