Cetyl Trimethoxysilane

INCI: CETYL TRIMETHOXYSILANE

CAS Number
16415-12-6
Function
Surface modifier, Skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR assessed related silanes as safe; FDA permits cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHS H315 (skin irritation) in 96.6% of classifications; GHS H319 (eye irritation) in 65.3%; methanol release on hydrolysis; CIR read-across from C8 silane may not fully extrapolate to C16

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Concern Level: Moderate

Frequently Asked Questions

Is Cetyl Trimethoxysilane safe in cosmetics?

GHS H315 (skin irritation) in 96.6% of classifications; GHS H319 (eye irritation) in 65.3%; methanol release on hydrolysis; CIR read-across from C8 silane may not fully extrapolate to C16 The EU classifies Cetyl Trimethoxysilane as "permitted". Safety rating: MODERATE.

Is Cetyl Trimethoxysilane allowed in the EU?

Cetyl Trimethoxysilane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cetyl Trimethoxysilane do in cosmetics?

Cetyl Trimethoxysilane functions as: Surface modifier, Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 16415-12-6.

What is the Margin of Safety for Cetyl Trimethoxysilane?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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