Is Cetyl Trimethoxysilane safe in cosmetics?
Cetyl Trimethoxysilane has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Cetyl Trimethoxysilane
Also known as: EINECS 240-464-3, UNII-975S1VH3IB
INCI: CETYL TRIMETHOXYSILANE
Cetyl Trimethoxysilane (CAS 16415-12-6) is a cosmetic cosmetic ingredient functioning as Surface modifier, Skin conditioning agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 16415-12-6 →
Auto-generated CPSR Part A draft with source citations
Function
Surface modifier, Skin conditioning agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
hexadecyl(trimethoxy)silane
InChIKey
RSKGMYDENCAJEN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR assessed related silanes as safe; FDA permits cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cetyl Trimethoxysilane.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hardener
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Cetyl Trimethoxysilane.
Known Synonyms
EINECS 240-464-3
UNII-975S1VH3IB
Chemical Function
Hardener
No specific technical function
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Cetyl Trimethoxysilane allowed in the EU?
Cetyl Trimethoxysilane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cetyl Trimethoxysilane do in cosmetics?
Cetyl Trimethoxysilane functions as: Surface modifier, Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 16415-12-6.
Is Cetyl Trimethoxysilane used outside cosmetics?
Cetyl Trimethoxysilane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cetyl Trimethoxysilane compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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