Is Chloroethyl PCA safe in cosmetics?
Chloroethyl PCA has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Chloroethyl PCA
INCI: CHLOROETHYL PCA
Chloroethyl PCA (CAS 159852-64-9) is a cosmetic cosmetic ingredient functioning as Humectant / skin conditioning agent (PCA derivative). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 159852-64-9 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant / skin conditioning agent (PCA derivative)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-chloroethyl 5-oxopyrrolidine-2-carboxylate
InChIKey
WRQQVUIATYAFKC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA UNII: B472383204. No specific restrictions; PCA and sodium PCA reviewed by CIR and found safe as used
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chloroethyl PCA.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Chloroethyl PCA.
Chemical Function
Humectant
Frequently Asked Questions
Is Chloroethyl PCA allowed in the EU?
Chloroethyl PCA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Chloroethyl PCA do in cosmetics?
Chloroethyl PCA functions as: Humectant / skin conditioning agent (PCA derivative). It is classified as a cosmetic ingredient in our database. CAS number: 159852-64-9.
Compliance Tools
Check Chloroethyl PCA compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Alanyl Glutamine
Excellent
Same category
Skin conditioning, humectant
Aloe Barbadensis Leaf Polysaccharides
Excellent
Same category
Humectant, skin conditioning
Aloe Barbadensis Leaf Water
Excellent
Same category
Skin conditioning, humectant
Alpha-Glucan
Excellent
Same category
Skin Conditioning, Film Forming, Hume...
Ammonium Hydrolyzed Collagen
Excellent
Same category
Antistatic; film forming; hair condit...
Arabinose
Excellent
Same category
Humectant / Moisturizing agent; promo...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
CHLAMYDOMONAS R-(OLIGOPEPTIDE-91 SH-POLYPEPTIDE-11 SH-POLYPEPTIDE-1 SH-POLYPEPTIDE-11)
Good
Browse nearby
Skin Conditioning, Viscosity Controlling
CHLORELLA VULGARIS OIL
Good
Browse nearby
Skin Conditioning - Emollient, Skin C...
CHLORHEXIDINE DIACETATE
Moderate
Browse nearby
Antimicrobial, Oral Care, Preservative
Is Chloroethyl PCA in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Chloroethyl PCA in your formulation.