Chloroethyl PCA

INCI: CHLOROETHYL PCA

CAS Number
159852-64-9
Function
Humectant / skin conditioning agent (PCA derivative)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA UNII: B472383204. No specific restrictions; PCA and sodium PCA reviewed by CIR and found safe as used

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hydrolysis may release 2-chloroethanol (toxic metabolite); requires read-across toxicological assessment; nitrosation concern. CIR Panel advises PCA ingredients not be used with nitrosating agents.

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Concern Level: High

Frequently Asked Questions

Is Chloroethyl PCA safe in cosmetics?

Hydrolysis may release 2-chloroethanol (toxic metabolite); requires read-across toxicological assessment; nitrosation concern. CIR Panel advises PCA ingredients not be used with nitrosating agents. The EU classifies Chloroethyl PCA as "permitted". Safety rating: MODERATE.

Is Chloroethyl PCA allowed in the EU?

Chloroethyl PCA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Chloroethyl PCA do in cosmetics?

Chloroethyl PCA functions as: Humectant / skin conditioning agent (PCA derivative). It is classified as a cosmetic ingredient in our database. CAS number: 159852-64-9.

What is the Margin of Safety for Chloroethyl PCA?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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