Is Cinnamyl Isovalerate safe in cosmetics?
Cinnamyl Isovalerate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Cinnamyl Isovalerate
Also known as: Cinnamyl 3-methyl butyrate, Cinnamyl 3-methylbutanoate, 3-Methylbutanoic acid 3-phenyl-2-propenyl ester, 3-Phenylallyl 3-methylbutanoate, 3-Phenyl-2-propenyl 3-methylbutanoate (+12 more)
INCI: CINNAMYL ISOVALERATE
Cinnamyl Isovalerate (CAS 140-27-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with fruity, balsamic, and herbaceous odor profile. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 140-27-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with fruity, balsamic, and herbaceous odor profile
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(E)-3-phenylprop-2-enyl] 3-methylbutanoate
InChIKey
FOCMOGKCPPTERB-RMKNXTFCSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; FEMA GRAS (flavor). No specific CIR review.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cinnamyl Isovalerate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
654
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-PHENYLALLYL 3-METHYLBUTANOATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-PHENYLALLYL ISOVALERATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CINNAMYL ISOVALERATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Cinnamyl Isovalerate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Cinnamyl 3-methyl butyrate
Cinnamyl 3-methylbutanoate
3-Methylbutanoic acid 3-phenyl-2-propenyl ester
3-Phenylallyl 3-methylbutanoate
3-Phenyl-2-propenyl 3-methylbutanoate
Butanoic acid, 3-methyl-, 3-phenyl-2-propenyl ester
Butanoic acid, 3-methyl-, 3-phenyl-2-propen-1-yl ester
3-Phenyl-2-propen-1-yl isovalerate
Cinnamyl alcohol, isovalerate
BRN 3201227
Cinnamyl isovalerianate
EINECS 205-407-9
FEMA No. 2302
Isovaleric acid, cinnamyl ester
NSC 46141
3-Phenylallyl isovalerate
UNII-5JHK9Y2XRM
Chemical Function
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
Australia; Food and drug - smoking-related products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4162391
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
CINNAMYL ISOVALERATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Cinnamyl Isovalerate allowed in the EU?
Cinnamyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cinnamyl Isovalerate do in cosmetics?
Cinnamyl Isovalerate functions as: Fragrance ingredient with fruity, balsamic, and herbaceous odor profile. It is classified as a cosmetic ingredient in our database. CAS number: 140-27-2.
Is Cinnamyl Isovalerate used outside cosmetics?
Cinnamyl Isovalerate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cinnamyl Isovalerate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Acetyl Glyceryl Ricinoleate
Good
Chemical family
Emollient, Skin Conditioning
Allylanisole
Moderate
Chemical family
Fragrance; denaturant
Benzyl Acetate
Excellent
Chemical family
Perfuming, Masking, Solvent
Is Cinnamyl Isovalerate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cinnamyl Isovalerate in your formulation.