Is cis-3-Hexenyl 2-Methylbutyrate safe in cosmetics?
cis-3-Hexenyl 2-Methylbutyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
cis-3-Hexenyl 2-Methylbutyrate
INCI: FRAGRANCE
cis-3-Hexenyl 2-Methylbutyrate (CAS 53398-83-7) is a cosmetic cosmetic ingredient functioning as Fragrance with green, fruity, berry, and strawberry notes. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 53398-83-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance with green, fruity, berry, and strawberry notes
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(E)-hex-2-enyl] butanoate
InChIKey
PCGACKLJNBBQGM-VOTSOKGWSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS; RIFM-assessed; no FDA cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl 2-Methylbutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
synergy
{"inci_name_2": "Cyclodextrin", "synergy_type": "color-stability", "synergy_description": "Encapsulation for fragrance protection and controlled release", "combined_benefit": "Extended fragrance longevity, reduced volatility, improved stability", "efficacy_multiplier": "2.3x", "mechanism_of_action": "Cyclodextrin encapsulates fragrance molecules protecting from oxidation and controlling release", …
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1375
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
trans-2-HEXENYL BUTANOATE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/151 | ">FAS 60-JECFA 69/628
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
trans-2-HEXENYL BUTYRATE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/151 | ">FAS 60-JECFA 69/628
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl 2-Methylbutyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
(E)-2-HEXENYL BUTYRATE
Food Category
flavoring
Frequently Asked Questions
Is cis-3-Hexenyl 2-Methylbutyrate allowed in the EU?
cis-3-Hexenyl 2-Methylbutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl 2-Methylbutyrate do in cosmetics?
cis-3-Hexenyl 2-Methylbutyrate functions as: Fragrance with green, fruity, berry, and strawberry notes. It is classified as a cosmetic ingredient in our database. CAS number: 53398-83-7.
Is cis-3-Hexenyl 2-Methylbutyrate used outside cosmetics?
cis-3-Hexenyl 2-Methylbutyrate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyl 2-Methylbutyrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Antioxidant
3-Hexenyl 2-Methylbutyrate
Good
Chemical family
Fragrance/Perfuming
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Excellent
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