Is cis-3-Hexenyl Benzoate safe in cosmetics?
cis-3-Hexenyl Benzoate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
cis-3-Hexenyl Benzoate
Also known as: EINECS 246-669-4, FEMA No. 3688, (Z)-3-Hexenyl benzoate, 3-Hexenyl benzoate, (Z)-, UNII-P4871S0YA9
INCI: CIS-3-HEXENYL BENZOATE
cis-3-Hexenyl Benzoate (CAS 25152-85-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with green, fruity, and slightly balsamic notes. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 25152-85-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with green, fruity, and slightly balsamic notes
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(Z)-hex-3-enyl] benzoate
InChIKey
BCOXBEHFBZOJJZ-ARJAWSKDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA-listed food substance (formerly EAFUS); FEMA GRAS #3688; JECFA #858; RIFM safety assessed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-3-Hexenyl Benzoate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
858
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
cis-3-HEXENYL BENZOATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/73 | FAS 48-JECFA 57/227
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for cis-3-Hexenyl Benzoate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
EINECS 246-669-4
FEMA No. 3688
(Z)-3-Hexenyl benzoate
3-Hexenyl benzoate, (Z)-
UNII-P4871S0YA9
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182851
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
CIS-3-HEXENYL BENZOATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is cis-3-Hexenyl Benzoate allowed in the EU?
cis-3-Hexenyl Benzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-3-Hexenyl Benzoate do in cosmetics?
cis-3-Hexenyl Benzoate functions as: Fragrance ingredient with green, fruity, and slightly balsamic notes. It is classified as a cosmetic ingredient in our database. CAS number: 25152-85-6.
Is cis-3-Hexenyl Benzoate used outside cosmetics?
cis-3-Hexenyl Benzoate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-3-Hexenyl Benzoate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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