Poor Cosmetic Ingredient NOAEL Data

Trans, Trans-2,4-Decadienal ⚠

INCI: TRANS, TRANS-2,4-DECADIENAL

CAS Number
25152-84-5
Function
Fragrance (fatty, oily, chicken fat odor)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes FEMA GRAS 3135 for flavor use only; IFRA prohibited for fragrance

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Trans, Trans-2,4-Decadienal ⚠. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 33.9 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 33.9 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

⚠ IFRA PROHIBITION on all 2,4-dienals; lipid peroxidation product with potential mutagenic activity; reactive aldehyde; air and light sensitive

⚠️
Concern Level: High

Regulatory Flags

fragrance-component fda_food_additive

Frequently Asked Questions

Is Trans, Trans-2,4-Decadienal ⚠ safe in cosmetics?

⚠ IFRA PROHIBITION on all 2,4-dienals; lipid peroxidation product with potential mutagenic activity; reactive aldehyde; air and light sensitive The EU classifies Trans, Trans-2,4-Decadienal ⚠ as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.

Is Trans, Trans-2,4-Decadienal ⚠ allowed in the EU?

Trans, Trans-2,4-Decadienal ⚠ EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Trans, Trans-2,4-Decadienal ⚠ do in cosmetics?

Trans, Trans-2,4-Decadienal ⚠ functions as: Fragrance (fatty, oily, chicken fat odor). It is classified as a cosmetic ingredient in our database. CAS number: 25152-84-5.

What is the Margin of Safety for Trans, Trans-2,4-Decadienal ⚠?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Trans, Trans-2,4-Decadienal ⚠?

The NOAEL (No Observed Adverse Effect Level) for Trans, Trans-2,4-Decadienal ⚠ is 33.9 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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