cis-3-Hexenyl Cinnamate

INCI: CIS-3-HEXENYL CINNAMATE

CAS Number
67674-36-6
Function
Fragrance ingredient (sweet, balsamic, green-floral)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes RIFM safety assessed; not individually CIR-reviewed; cleared via RIFM framework

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Cinnamate moiety is a structural alert for skin sensitization — the α,β-unsaturated carbonyl can act as a Michael acceptor; UV absorption potential from cinnamate chromophore requires phototoxicity evaluation; this is the highest-risk ingredient for CPSR purposes.

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Concern Level: High

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is cis-3-Hexenyl Cinnamate safe in cosmetics?

Cinnamate moiety is a structural alert for skin sensitization — the α,β-unsaturated carbonyl can act as a Michael acceptor; UV absorption potential from cinnamate chromophore requires phototoxicity evaluation; this is the highest-risk ingredient for CPSR purposes. The EU classifies cis-3-Hexenyl Cinnamate as "prohibited". Safety rating: MODERATE.

Is cis-3-Hexenyl Cinnamate allowed in the EU?

cis-3-Hexenyl Cinnamate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does cis-3-Hexenyl Cinnamate do in cosmetics?

cis-3-Hexenyl Cinnamate functions as: Fragrance ingredient (sweet, balsamic, green-floral). It is classified as a cosmetic ingredient in our database. CAS number: 67674-36-6.

What is the Margin of Safety for cis-3-Hexenyl Cinnamate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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