Is cis-6-Nonenal safe in cosmetics?
cis-6-Nonenal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
cis-6-Nonenal
Also known as: 6-Nonenal, (6Z)-, BRN 2323664, EINECS 218-900-9, FEMA No. 3580, (Z)-6-Nonenal (+2 more)
INCI: CIS-6-NONENAL
cis-6-Nonenal (CAS 2277-19-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Fragrance ingredient
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(Z)-non-6-enal
InChIKey
RTNPCOBSXBGDMO-ARJAWSKDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific CIR review; assessed by RIFM — supported for use as described in safety assessment
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for cis-6-Nonenal.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
8%
DPRA Lys %
2.7%
KeratinoSens IC50
381.575 µM
LLNA EC3
23%
NESIL
675 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Human: positive
Source: LLNA: Gerberick et al. (2005); DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; HPPT: [445] Epstein WL (1978): Report to RIFM, 28 April, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
325
Source: WHO/JECFA
JECFA Evaluation
cis-6-NONENAL | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 42-JECFA 51/267 (1998)
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for cis-6-Nonenal — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
6-Nonenal, (6Z)-
BRN 2323664
EINECS 218-900-9
FEMA No. 3580
(Z)-6-Nonenal
cis-6-Nonen-1-al
UNII-D8027Y6086
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
CIS-6-NONENAL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is cis-6-Nonenal allowed in the EU?
cis-6-Nonenal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does cis-6-Nonenal do in cosmetics?
cis-6-Nonenal functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2277-19-2.
Is cis-6-Nonenal used outside cosmetics?
cis-6-Nonenal also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check cis-6-Nonenal compliance across multiple jurisdictions:
Ingredient Decoder
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Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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