Cobamamide

INCI: COBAMAMIDE

CAS Number
13870-90-1
Function
Antioxidant, skin protecting, skin conditioning
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA UNII: F0R1QK73KB. Recognized as a form of vitamin B12. No restrictions for cosmetic use. Also has ATC code B03BA04 (pharmaceutical use).

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Light-sensitive ingredient requiring storage protection at โˆ’20ยฐC and UV protection during formulation to prevent degradation. No sensitization, irritation, or systemic toxicity concerns at cosmetic use levels.

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Concern Level: Low

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Cobamamide safe in cosmetics?

Light-sensitive ingredient requiring storage protection at โˆ’20ยฐC and UV protection during formulation to prevent degradation. No sensitization, irritation, or systemic toxicity concerns at cosmetic use levels. The EU classifies Cobamamide as "permitted". Safety rating: EXCELLENT.

Is Cobamamide allowed in the EU?

Cobamamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cobamamide do in cosmetics?

Cobamamide functions as: Antioxidant, skin protecting, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 13870-90-1.

What is the Margin of Safety for Cobamamide?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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