Is CI 75170 (Guanine) safe in cosmetics?
CI 75170 (Guanine) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
CI 75170 (Guanine)
Also known as: EINECS 200-799-8, UNII-5Z93L87A1R, 2-Amino-1,9-dihydro-6H-purin-6-one, 2-Amino-1,9-dihydro-purin-6-one, 2-Amino-3,7-dihydro-6H-purin-6-one (+12 more)
INCI: CI 75170
CI 75170 (Guanine) (CAS 73-40-5) is a cosmetic cosmetic ingredient functioning as Colorant. Natural crystalline material derived from fish scales (principally. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 73-40-5 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant. Natural crystalline material derived from fish scales (principally guanine and hypoxanthine in approximately 75:25 ratio); also known as Guanine and Natural White 1. Imparts a pearlescent, iridescent, light-reflecting shimmer to cosmetic products. Non-opacity white and pearl-luster effect pigment. Used in nail polishes, eyeshadows, lip products, and skin-illuminating preparations. Regulated under EU Annex IV Restriction IV/113.
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-amino-1,7-dihydropurin-6-one
InChIKey
UYTPUPDQBNUYGX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA permanently lists Guanine as a color additive exempt from certification for use in externally applied drugs including eye area use (21 CFR 73.1329) and cosmetics generally including eye area use (21 CFR 73.2329). Permitted in both drug and cosmetic products at levels consistent with good manufacturing practice.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 75170 (Guanine).
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: White
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "Guaiazulene", "Chemical_Name": "Guaiazulene", "CAS_Number": "489-84-9", "Colorant_Type": "Natural Colorant", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved", "Notes": "Blue from chamomile"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Opacifer
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 75170 (Guanine).
Regulatory Flags
natural-colorant
eu-annex-iv
fda-exempt-certification
fish-derived
pearlescent
iridescent
eye-area-permitted
vegan-concern
insoluble-pigment
mineral-type
eu_cosing_listed
Known Synonyms
EINECS 200-799-8
UNII-5Z93L87A1R
2-Amino-1,9-dihydro-6H-purin-6-one
2-Amino-1,9-dihydro-purin-6-one
2-Amino-3,7-dihydro-6H-purin-6-one
2-Amino-6-purinol
2-Amino-Hypoxanthine
2-amino-6,7-dihydro-3H-purin-6-one
2-amino-6-oxopurine
6-Hydroxy-2-aminopurine
CI Natural white 1
GUN
Gua
Guanin
Mearlmaid
Naturon
Pathocidin
Chemical Function
Dye
Opacifer
Regulatory Lists
Europe; Personal care
pharmaceutical
Personal care
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GUANINE
ChEMBL ID
CHEMBL219568
Max Phase
3
Frequently Asked Questions
Is CI 75170 (Guanine) allowed in the EU?
CI 75170 (Guanine) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 75170 (Guanine) do in cosmetics?
CI 75170 (Guanine) functions as: Colorant. Natural crystalline material derived from fish scales (principally guanine and hypoxanthine in approximately 75:25 ratio); also known as Guanine and Natural White 1. Imparts a pearlescent, iridescent, light-reflecting shimmer to cosmetic products. Non-opacity white and pearl-luster effect pigment. Used in nail polishes, eyeshadows, lip products, and skin-illuminating preparations. Regulated under EU Annex IV Restriction IV/113.. It is classified as a cosmetic ingredient in our database. CAS number: 73-40-5.
Is CI 75170 (Guanine) used outside cosmetics?
CI 75170 (Guanine) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 75170 (Guanine) compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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