Excellent Cosmetic Ingredient

CI 75170 (Guanine)

INCI: CI 75170

CAS Number

73-40-5

Function

Colorant. Natural crystalline material derived from fish scales (principally guanine and hypoxanthine in approximately 75:25 ratio); also known as Guanine and Natural White 1. Imparts a pearlescent, iridescent, light-reflecting shimmer to cosmetic products. Non-opacity white and pearl-luster effect pigment. Used in nail polishes, eyeshadows, lip products, and skin-illuminating preparations. Regulated under EU Annex IV Restriction IV/113.

Safety Rating

EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes FDA permanently lists Guanine as a color additive exempt from certification for use in externally applied drugs including eye area use (21 CFR 73.1329) and cosmetics generally including eye area use (21 CFR 73.2329). Permitted in both drug and cosmetic products at levels consistent with good manufacturing practice.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

negligible

Sensitization

none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CI 75170 (Guanine / Natural White 1) is a well-established pearl-luster cosmetic colorant derived from fish scales, listed in EU Cosmetics Regulation Annex IV (Restriction IV/113) as permitted and granted FDA permanent listing exempt from batch certification for drugs and cosmetics including eye area use. Excellent safety record with no identified concerns; note that this is an animal-derived (fish) ingredient relevant for vegan formulations.

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Concern Level: None

Regulatory Flags

natural-colorant eu-annex-iv fda-exempt-certification fish-derived pearlescent iridescent eye-area-permitted vegan-concern insoluble-pigment mineral-type eu_cosing_listed

Frequently Asked Questions

Is CI 75170 (Guanine) safe in cosmetics?

Is CI 75170 (Guanine) allowed in the EU?

CI 75170 (Guanine) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 75170 (Guanine) do in cosmetics?

CI 75170 (Guanine) functions as: Colorant. Natural crystalline material derived from fish scales (principally guanine and hypoxanthine in approximately 75:25 ratio); also known as Guanine and Natural White 1. Imparts a pearlescent, iridescent, light-reflecting shimmer to cosmetic products. Non-opacity white and pearl-luster effect pigment. Used in nail polishes, eyeshadows, lip products, and skin-illuminating preparations. Regulated under EU Annex IV Restriction IV/113.. It is classified as a cosmetic ingredient in our database. CAS number: 73-40-5.

What is the Margin of Safety for CI 75170 (Guanine)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check CI 75170 (Guanine) compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

Check compliance across 55 jurisdictions

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

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