Crystallins

INCI: CRYSTALLINS

CAS Number
11046-99-4
Function
Skin conditioning, hair conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA restriction; permitted for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Source-dependent safety (bovine vs. recombinant vs. synthetic peptide mimetics); BSE/TSE compliance mandatory if animal-derived; confirm origin documentation for EU Novel Food/Cosmetics compliance; synthetic peptide variants like Palmitoyl Tetrapeptide-10 promote endogenous alpha-crystallin with separate safety data.

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Concern Level: Moderate

Frequently Asked Questions

Is Crystallins safe in cosmetics?

Source-dependent safety (bovine vs. recombinant vs. synthetic peptide mimetics); BSE/TSE compliance mandatory if animal-derived; confirm origin documentation for EU Novel Food/Cosmetics compliance; synthetic peptide variants like Palmitoyl Tetrapeptide-10 promote endogenous alpha-crystallin with separate safety data. The EU classifies Crystallins as "permitted". Safety rating: MODERATE.

Is Crystallins allowed in the EU?

Crystallins EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Crystallins do in cosmetics?

Crystallins functions as: Skin conditioning, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 11046-99-4.

What is the Margin of Safety for Crystallins?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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