Regulatory Status
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Safety Data
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Expert Verdict
High caution required. Cucurbitacin B is a cytotoxic tetracyclic triterpenoid with documented anti-proliferative, pro-apoptotic, and hepatotoxic effects at elevated doses; systemic toxicity is a concern if used at inappropriate concentrations; thorough safety assessment mandatory before formulation. Intensely bitter compound found in wild cucurbits; studied extensively in oncology research for anti-tumor activity; anti-inflammatory properties at very low concentrations; requires precise dose ...
Frequently Asked Questions
Is Cucurbitacin B safe in cosmetics?
High caution required. Cucurbitacin B is a cytotoxic tetracyclic triterpenoid with documented anti-proliferative, pro-apoptotic, and hepatotoxic effects at elevated doses; systemic toxicity is a concern if used at inappropriate concentrations; thorough safety assessment mandatory before formulation. Intensely bitter compound found in wild cucurbits; studied extensively in oncology research for anti-tumor activity; anti-inflammatory properties at very low concentrations; requires precise dose ... The EU classifies Cucurbitacin B as "permitted". Safety rating: MODERATE.
Is Cucurbitacin B allowed in the EU?
Cucurbitacin B EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cucurbitacin B do in cosmetics?
Cucurbitacin B functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 6199-67-3.
What is the Margin of Safety for Cucurbitacin B?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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