Moderate Cosmetic Ingredient NOAEL Data

Curcuma Zedoaria Root Extract

INCI: CURCUMA ZEDOARIA ROOT EXTRACT

CAS Number
84961-49-9
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no specific FDA restrictions on botanical extracts

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Curcuma Zedoaria Root Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 137 mg/kg bw/day oral rabbit Special Toxicology Study COSMOS_DB
NOAEL 1500 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB

Expert Verdict

Skin sensitization risk flagged for volatile fraction; limited published toxicological data; no dedicated SCCS/CIR review; supplier must provide toxicological dossier for CPSR.

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Concern Level: Moderate

Regulatory Flags

plant-extract potential-allergen fda_food_additive

Frequently Asked Questions

Is Curcuma Zedoaria Root Extract safe in cosmetics?

Skin sensitization risk flagged for volatile fraction; limited published toxicological data; no dedicated SCCS/CIR review; supplier must provide toxicological dossier for CPSR. The EU classifies Curcuma Zedoaria Root Extract as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Curcuma Zedoaria Root Extract allowed in the EU?

Curcuma Zedoaria Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Curcuma Zedoaria Root Extract do in cosmetics?

Curcuma Zedoaria Root Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84961-49-9.

What is the Margin of Safety for Curcuma Zedoaria Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Curcuma Zedoaria Root Extract?

The NOAEL (No Observed Adverse Effect Level) for Curcuma Zedoaria Root Extract is 137 mg/kg bw/day based on a Special Toxicology Study study via oral route in rabbit. A total of 2 study endpoints are available. Source: COSMOS_DB.

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