Cyclohexanediamine Tetraacetic Acid

INCI: CYCLOHEXANEDIAMINE TETRAACETIC ACID

CAS Number
482-54-2 (cyclohexane-1,2-diamine-N,N,N',N'-tetraacetic acid)
Function
Chelating agent that binds metal ions and improves product stability.
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not covered by a specific CIR monograph; use as a chelating agent would fall under general cosmetic safety provisions.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Classified as causing skin and serious eye irritation and harmful if inhaled in GHS classification. Manufacturing handling must follow appropriate PPE; rinse-off products preferable if data gaps remain. Environmental persistence and metal-complexing capacity should be evaluated similarly to EDTA.

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Concern Level: Moderate

Frequently Asked Questions

Is Cyclohexanediamine Tetraacetic Acid safe in cosmetics?

Classified as causing skin and serious eye irritation and harmful if inhaled in GHS classification. Manufacturing handling must follow appropriate PPE; rinse-off products preferable if data gaps remain. Environmental persistence and metal-complexing capacity should be evaluated similarly to EDTA. The EU classifies Cyclohexanediamine Tetraacetic Acid as "prohibited". Safety rating: GOOD.

Is Cyclohexanediamine Tetraacetic Acid allowed in the EU?

Cyclohexanediamine Tetraacetic Acid EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclohexanediamine Tetraacetic Acid do in cosmetics?

Cyclohexanediamine Tetraacetic Acid functions as: Chelating agent that binds metal ions and improves product stability.. It is classified as a cosmetic ingredient in our database. CAS number: 482-54-2 (cyclohexane-1,2-diamine-N,N,N',N'-tetraacetic acid).

What is the Margin of Safety for Cyclohexanediamine Tetraacetic Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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