Good Cosmetic Ingredient NOAEL Data GHS Classified

Cyclohexanol

INCI: CYCLOHEXANOL

CAS Number
108-93-0
Function
Fragrance ingredient and possible solvent; assessed as a fragrance material by the Research Institute for Fragrance Materials (RIFM).
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Evaluated by RIFM; no specific FDA cosmetic restriction; use levels are self-regulated via IFRA Standards and internal safety assessments.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Cyclohexanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 143 mg/kg bw/day oral rat oral REACH
NOAEL 200 mg/kg bw/day 2011 rat other REACH
NOAEL 143 mg/kg bw/day oral - oral REACH
NOAEL 462 mg/kg bw/day oral code:3544 oral REACH
LOAEL 15 mg/kg bw/day 2400 rat other REACH
LOAEL 2.78 2101 1991 monkey inhalation REACH
LOAEL 0.58 2101 1991 rabbit inhalation REACH
LOAEL 455 mg/kg bw/day oral rat oral REACH
LOAEL 15 mg/kg bw/day 2400 code:1942 other REACH
LOAEL 25 mg/kg bw/day oral rabbit oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Expert Verdict

Local respiratory toxicity and phototoxicity/photoallergenicity were evaluated and not considered concerns at use levels. Neat material is irritating and flammable; IFRA limits and typical fragrance handling controls should be followed.

⚠️
Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is Cyclohexanol safe in cosmetics?

Local respiratory toxicity and phototoxicity/photoallergenicity were evaluated and not considered concerns at use levels. Neat material is irritating and flammable; IFRA limits and typical fragrance handling controls should be followed. The EU classifies Cyclohexanol as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Cyclohexanol allowed in the EU?

Cyclohexanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclohexanol do in cosmetics?

Cyclohexanol functions as: Fragrance ingredient and possible solvent; assessed as a fragrance material by the Research Institute for Fragrance Materials (RIFM).. It is classified as a cosmetic ingredient in our database. CAS number: 108-93-0.

What is the Margin of Safety for Cyclohexanol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Cyclohexanol?

The NOAEL (No Observed Adverse Effect Level) for Cyclohexanol is 143 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

Compliance Tools

Check Cyclohexanol compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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