Good Cosmetic Ingredient

D-Nonapeptide-1

INCI: D-NONAPEPTIDE-1

CAS Number
158563-45-2 (Nonapeptide-1; Melanostatine-5)
Function
Skin-brightening and anti-pigmentation peptide; selective MC1R antagonist that inhibits α-MSH signaling, reduces melanin synthesis, and evens skin tone
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted; cosmetic use is acceptable provided the product does not make drug claims and safety is substantiated; mechanism overlaps with melanocortin signaling but is considered cosmetic when used for appearance of pigmentation

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Mechanistic modulation of pigmentation pathways; ensure absence of off-target endocrine effects and systemic melanocortin receptor interference; avoid use on compromised skin and in high-dose body applications without supporting tox data

⚠️
Concern Level: Low

Frequently Asked Questions

Is D-Nonapeptide-1 safe in cosmetics?

Mechanistic modulation of pigmentation pathways; ensure absence of off-target endocrine effects and systemic melanocortin receptor interference; avoid use on compromised skin and in high-dose body applications without supporting tox data The EU classifies D-Nonapeptide-1 as "permitted". Safety rating: GOOD.

Is D-Nonapeptide-1 allowed in the EU?

D-Nonapeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does D-Nonapeptide-1 do in cosmetics?

D-Nonapeptide-1 functions as: Skin-brightening and anti-pigmentation peptide; selective MC1R antagonist that inhibits α-MSH signaling, reduces melanin synthesis, and evens skin tone. It is classified as a cosmetic ingredient in our database. CAS number: 158563-45-2 (Nonapeptide-1; Melanostatine-5).

What is the Margin of Safety for D-Nonapeptide-1?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check D-Nonapeptide-1 compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Vanilla Planifolia Seed Powder
Good
Aluminum Dichlorohydrex PG
Good
Perfluoromethylcyclopentane
Moderate
Acetyl Hexapeptide-7
Moderate
Dimethylolcyclohexane Dibenzoate
Moderate
Browse all 30,000+ ingredients →
📱

Is D-Nonapeptide-1 in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for D-Nonapeptide-1 in your formulation.

Ingredient Decoder MoS Calculator