Is D-Nonapeptide-1 safe in cosmetics?
D-Nonapeptide-1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
D-Nonapeptide-1
INCI: D-NONAPEPTIDE-1
D-Nonapeptide-1 (CAS 158563-45-2 (Nonapeptide-1; Melanostatine-5)) is a cosmetic cosmetic ingredient functioning as Skin-brightening and anti-pigmentation peptide; selective MC1R antagonist that. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 158563-45-2 (Nonapeptide-1; Melanostatine-5) →
Auto-generated CPSR Part A draft with source citations
Function
Skin-brightening and anti-pigmentation peptide; selective MC1R antagonist that inhibits α-MSH signaling, reduces melanin synthesis, and evens skin tone
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted; cosmetic use is acceptable provided the product does not make drug claims and safety is substantiated; mechanism overlaps with melanocortin signaling but is considered cosmetic when used for appearance of pigmentation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for D-Nonapeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for D-Nonapeptide-1.
Frequently Asked Questions
Is D-Nonapeptide-1 allowed in the EU?
D-Nonapeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does D-Nonapeptide-1 do in cosmetics?
D-Nonapeptide-1 functions as: Skin-brightening and anti-pigmentation peptide; selective MC1R antagonist that inhibits α-MSH signaling, reduces melanin synthesis, and evens skin tone. It is classified as a cosmetic ingredient in our database. CAS number: 158563-45-2 (Nonapeptide-1; Melanostatine-5).
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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