Decapeptide-53 Amide

INCI: DECAPEPTIDE-53 AMIDE

CAS Number
Not assigned in CosIng; request from supplier
Function
Skin conditioning (synthetic peptide, C-terminal amidated)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Amidated C-terminus may increase metabolic stability and bioactivity versus free-acid form; requires supplier safety dossier; no published toxicological data.

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Concern Level: Moderate

Frequently Asked Questions

Is Decapeptide-53 Amide safe in cosmetics?

Amidated C-terminus may increase metabolic stability and bioactivity versus free-acid form; requires supplier safety dossier; no published toxicological data. The EU classifies Decapeptide-53 Amide as "permitted". Safety rating: MODERATE.

Is Decapeptide-53 Amide allowed in the EU?

Decapeptide-53 Amide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Decapeptide-53 Amide do in cosmetics?

Decapeptide-53 Amide functions as: Skin conditioning (synthetic peptide, C-terminal amidated). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned in CosIng; request from supplier.

What is the Margin of Safety for Decapeptide-53 Amide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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