Denatured Lysozyme

INCI: DENATURED LYSOZYME

CAS Number
12650-88-3 (lysozyme base); denatured form has no separate CAS
Function
Antimicrobial
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Denatured lysozyme reduces cell metabolic activity and increases inflammatory cytokine release in epithelial cells; animal origin (hen egg white) presents allergen concern for egg-sensitive individuals; denatured conformation may alter immunogenicity compared to native lysozyme; allergen disclosure required.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Denatured Lysozyme safe in cosmetics?

Denatured lysozyme reduces cell metabolic activity and increases inflammatory cytokine release in epithelial cells; animal origin (hen egg white) presents allergen concern for egg-sensitive individuals; denatured conformation may alter immunogenicity compared to native lysozyme; allergen disclosure required. The EU classifies Denatured Lysozyme as "restricted". Safety rating: MODERATE.

Is Denatured Lysozyme allowed in the EU?

Denatured Lysozyme EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Denatured Lysozyme do in cosmetics?

Denatured Lysozyme functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 12650-88-3 (lysozyme base); denatured form has no separate CAS.

What is the Margin of Safety for Denatured Lysozyme?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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