Excellent Cosmetic Ingredient NOAEL Data

Dextrin

INCI: DEXTRIN

CAS Number

9004-53-9

Function

Binding agent, film forming, skin conditioning, viscosity controlling

Safety Rating

EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Permitted — FDA GRAS food additive; CIR Expert Panel concluded safe as used in cosmetics (Polysaccharide Gums assessment)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

negligible

Sensitization

none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Dextrin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	65000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	10000 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB
NOAEL	71000 mg/kg bw/day	oral	rat	Special Toxicology Study	COSMOS_DB
NOAEL	35300 mg/kg bw/day	oral	rat	Special Toxicology Study	COSMOS_DB
NOAEL	5000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	15000 mg/kg bw/day	oral	mouse	Short Term Toxicity	COSMOS_DB
NOAEL	50000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
dose_tested	10000 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB

Expert Verdict

Safe at cosmetic use levels; confirm source (corn, potato, tapioca) for allergen labeling if gluten-containing grain source; ensure cGMP to limit impurities

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Concern Level: Low

Regulatory Flags

potential-allergen epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Dextrin safe in cosmetics?

Safe at cosmetic use levels; confirm source (corn, potato, tapioca) for allergen labeling if gluten-containing grain source; ensure cGMP to limit impurities The EU classifies Dextrin as "permitted". Safety rating: EXCELLENT. 8 toxicological study endpoint(s) are available in our database.

Is Dextrin allowed in the EU?

Dextrin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dextrin do in cosmetics?

Dextrin functions as: Binding agent, film forming, skin conditioning, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 9004-53-9.

What is the Margin of Safety for Dextrin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dextrin?

The NOAEL (No Observed Adverse Effect Level) for Dextrin is 65000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Dextrin compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

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